Evaluation of the anti-migration effect of barbed prostatic stents: In vitro study in urethra-mimicking bovine pericardium phantoms

Han Kyu Na, Ho Young Song, Jin Hyoung Kim, Deok Ho Nam, Jung Hoon Park, In Gab Jeong, Choung Soo Kim

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: This study was designed to compare the migration rates of covered stents with eight, four, and zero barbs in urethra-mimicking bovine pericardium models. Methods: Three types of polytetrafluoroethylene-covered retrievable self-expandable prostatic stents, with eight, four, and zero barbs, were tested in bovine pericardium models, consisting of normal saline-filled acrylic containers with tubes at both ends and a replica of the human urethra. The barbs were 2 mm in length and projected 60 toward the urinary bladder. The anti-migration force (AMF) and resistance force against stent removal (RFSR) were measured by an automatic push-pull gauge system at a fixed rate (2 mm/s). Results: Significant differences in AMF among the three stent types were detected (P < 0.001). Median AMF was far greater for eight-barbed than for four-barbed stents (11.96 vs. 7.55 N, P = 0.003). For stent removal, the difference between 4- and 8-barbed stents were not significant in median static (5.54 vs. 6.08 N, P = 0.15) or sliding (prostatic urethra, 5.32 vs. 5.59 N, P = 0.65; membranous urethra, 7.78 vs. 8.57 N, P = 0.364) RFSR. No perforations or scratched traces were observed during removal of these stents. Conclusions: The inclusion of eight barbs projecting 60 toward the urinary bladder were not only effective against stent migration in this model but suggests that these stents may be suitable for the treatment of prostatic urethral strictures without severely irritating the tissue. However, whether these results translate into living urethral tissue is unclear, necessitating further studies.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalCardiovascular and Interventional Radiology
Volume36
Issue number1
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

Keywords

  • Barbed stent
  • Benign prostatic hyperplasia
  • In vitro study
  • Prostatic stent
  • Stent migration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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