Evaluation of the accuracy and precision of the diffusion parameter EStImation with Gibbs and NoisE removal pipeline

Benjamin Ades-Aron, Jelle Veraart, Peter Kochunov, Stephen McGuire, Paul Sherman, Elias Kellner, Dmitry S. Novikov, Els Fieremans

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


This work evaluates the accuracy and precision of the Diffusion parameter EStImation with Gibbs and NoisE Removal (DESIGNER) pipeline, developed to identify and minimize common sources of methodological variability including: thermal noise, Gibbs ringing artifacts, Rician bias, EPI and eddy current induced spatial distortions, and motion-related artifacts. Following this processing pipeline, iterative parameter estimation techniques were used to derive diffusion parameters of interest based on the diffusion tensor and kurtosis tensor. We evaluated accuracy using a software phantom based on 36 diffusion datasets from the Human Connectome project and tested the precision by analyzing data from 30 healthy volunteers scanned three times within one week. Preprocessing with both DESIGNER or a standard pipeline based on smoothing (instead of noise removal) improved parameter precision by up to a factor of 2 compared to preprocessing with motion correction alone. When evaluating accuracy, we report average decreases in bias (deviation from simulated parameters) over all included regions for fractional anisotropy, mean diffusivity, mean kurtosis, and axonal water fraction of 9.7%, 8.7%, 4.2%, and 7.6% using DESIGNER compared to the standard pipeline, demonstrating that preprocessing with DESIGNER improves accuracy compared to other processing methods.

Original languageEnglish (US)
Pages (from-to)532-543
Number of pages12
StatePublished - Dec 2018
Externally publishedYes


  • Artifact correction
  • Denoising
  • Diffusion MRI
  • Gibbs ringing
  • Image processing

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


Dive into the research topics of 'Evaluation of the accuracy and precision of the diffusion parameter EStImation with Gibbs and NoisE removal pipeline'. Together they form a unique fingerprint.

Cite this