Evaluation of [99mTc] liposomes as lymphoscintigraphic agents: Comparison with [99mTc] sulfur colloid and [99mTc] human serum albumin

William T. Phillips, Trevor Andrews, Ho Ling Liu, Robert Klipper, Alfred J. Landry, Ralph Blumhardt, Beth Goins

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

This study investigates the use of [99mTc] liposomes for the detection of sentinel lymph nodes. A variety of [99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [99mTc] regular-sulfur colloid (SC), [99mTc] 0.22 μ-filtered-SC, [99mTc] reduced heating time 0.22 μ-filtered-SC, and [99mTc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [99mTc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [99mTc] filtered SC preparations > [99mTc] regular SC > [99mTc] liposomes > [99mTc] HSA. [99mTc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalNuclear Medicine and Biology
Volume28
Issue number4
DOIs
StatePublished - Jun 21 2001

Keywords

  • HMPAO
  • Liposomes
  • Lymphoscintigraphy
  • Sentinel node
  • Technetium-99m

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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