Evaluation of single-agent therapy in human colorectal tumour xenografts

P. J. Houghton, J. A. Houghton

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23 Scopus citations

Abstract

The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been quantified by growth inhibition, and the time taken for 3H-thymidine fractional incorporation (TFI) to recover to the control value after treatment. The chemosensitivity of each tumour line to a spectrum of agents was individual, and no pattern of response which would allow prediction of individual agent efficacy was apparent. Cyclophosphamide, methyl-CCNU and 5-fluorouracil produced marked growth inhibition in individual tumour lines, whereas actinomycin-D, cis-dichlorodiammine platinum, doxorubicin and pentamethylmelamine showed little activity. Data presented agree with clinical evaluation for single-agent therapy. The uptake and incorporation of radiolabelled 5-fluorouracil into 4 tumour lines is reported. No marked differences between 3 FU-insensitive lines and 1 sensitive line have been observed.

Original languageEnglish (US)
Pages (from-to)833-840
Number of pages8
JournalBritish Journal of Cancer
Volume37
Issue number5
DOIs
Publication statusPublished - May 1978

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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