Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation

John D Olson, W. J. Brockway, D. N. Fass, M. A. Magnuson, E. J. Bowie

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin induced platelet aggregation of platelet rich plasma was abnormal in all patients with von Willebrand's disease tested, and it was possible to correct this abnormal response by addition of normal platelet poor plasma. Abnormal ristocetin induced platelet aggregation was seen in patients with intrinsic platelet disorders or, on some occasions, in normal patients who had ingested aspirin. Ristocetin induced platelet aggregation is not diagnostic, but it may be useful as a simple screening test for patients with possible von Willebrand's disease. In conjunction with other tests, the assay for ristocetin Willebrand factor will be useful in diagnosis and evaluation of these patients.

Original languageEnglish (US)
Pages (from-to)210-218
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume63
Issue number2
StatePublished - 1975
Externally publishedYes

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Ristocetin
von Willebrand Factor
Platelet Aggregation
von Willebrand Diseases
Blood Platelets
Platelet-Rich Plasma
Aspirin
Hemorrhage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Olson, J. D., Brockway, W. J., Fass, D. N., Magnuson, M. A., & Bowie, E. J. (1975). Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation. American Journal of Clinical Pathology, 63(2), 210-218.

Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation. / Olson, John D; Brockway, W. J.; Fass, D. N.; Magnuson, M. A.; Bowie, E. J.

In: American Journal of Clinical Pathology, Vol. 63, No. 2, 1975, p. 210-218.

Research output: Contribution to journalArticle

Olson, JD, Brockway, WJ, Fass, DN, Magnuson, MA & Bowie, EJ 1975, 'Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation', American Journal of Clinical Pathology, vol. 63, no. 2, pp. 210-218.
Olson, John D ; Brockway, W. J. ; Fass, D. N. ; Magnuson, M. A. ; Bowie, E. J. / Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation. In: American Journal of Clinical Pathology. 1975 ; Vol. 63, No. 2. pp. 210-218.
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