Abstract
Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin induced platelet aggregation of platelet rich plasma was abnormal in all patients with von Willebrand's disease tested, and it was possible to correct this abnormal response by addition of normal platelet poor plasma. Abnormal ristocetin induced platelet aggregation was seen in patients with intrinsic platelet disorders or, on some occasions, in normal patients who had ingested aspirin. Ristocetin induced platelet aggregation is not diagnostic, but it may be useful as a simple screening test for patients with possible von Willebrand's disease. In conjunction with other tests, the assay for ristocetin Willebrand factor will be useful in diagnosis and evaluation of these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-218 |
| Number of pages | 9 |
| Journal | American Journal of Clinical Pathology |
| Volume | 63 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation. / Olson, John D; Brockway, W. J.; Fass, D. N.; Magnuson, M. A.; Bowie, E. J.
In: American Journal of Clinical Pathology, Vol. 63, No. 2, 1975, p. 210-218.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of ristocetin. Willebrand factor assay and ristocetin induced platelet aggregation
AU - Olson, John D
AU - Brockway, W. J.
AU - Fass, D. N.
AU - Magnuson, M. A.
AU - Bowie, E. J.
PY - 1975
Y1 - 1975
N2 - Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin induced platelet aggregation of platelet rich plasma was abnormal in all patients with von Willebrand's disease tested, and it was possible to correct this abnormal response by addition of normal platelet poor plasma. Abnormal ristocetin induced platelet aggregation was seen in patients with intrinsic platelet disorders or, on some occasions, in normal patients who had ingested aspirin. Ristocetin induced platelet aggregation is not diagnostic, but it may be useful as a simple screening test for patients with possible von Willebrand's disease. In conjunction with other tests, the assay for ristocetin Willebrand factor will be useful in diagnosis and evaluation of these patients.
AB - Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin induced platelet aggregation of platelet rich plasma was abnormal in all patients with von Willebrand's disease tested, and it was possible to correct this abnormal response by addition of normal platelet poor plasma. Abnormal ristocetin induced platelet aggregation was seen in patients with intrinsic platelet disorders or, on some occasions, in normal patients who had ingested aspirin. Ristocetin induced platelet aggregation is not diagnostic, but it may be useful as a simple screening test for patients with possible von Willebrand's disease. In conjunction with other tests, the assay for ristocetin Willebrand factor will be useful in diagnosis and evaluation of these patients.
UR - http://www.scopus.com/inward/record.url?scp=0016612738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016612738&partnerID=8YFLogxK
M3 - Article
C2 - 1078748
AN - SCOPUS:0016612738
VL - 63
SP - 210
EP - 218
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 2
ER -