Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

Randy Strong, Richard A. Miller, Clinton M. Astle, Joseph A. Baur, Rafael De Cabo, Elizabeth Fernandez, Wen Guo, Martin Javors, James L. Kirkland, James F. Nelson, David A. Sinclair, Bruce Teter, David Williams, Nurulain Zaveri, Nancy L. Nadon, David E. Harrison

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.

Original languageEnglish (US)
Pages (from-to)6-16
Number of pages11
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Interventions
  • Longevity
  • aging
  • diet
  • mice

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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