Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans

Farook Thameem, Xin He, V. Saroja Voruganti, Subrata D. Nath, Paolo Fanti, John Blangero, Jean W. MacCluer, Anthony G. Comuzzie, Nedal H. Arar, Hanna E. Abboud

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background/Aims: Genetic polymorphisms in the paraoxonase 2 (PON2) gene are thought to alter its activity and contribute to the development of cardiovascular and renal disease risk. The purpose of this study is to determine whether the Arg148Gly, Cys311Ser and rs12794795 polymorphisms of PON2 examined previously by others, are associated with type 2 diabetes (T2DM), and subclinical measures of cardiovascular and renal disease risk in Mexican Americans. Methods: Study participants (n = 848; 21 families) were genotyped for the three polymorphisms by TaqMan assay. Association between the genotypic and phenotypic data was performed by measured genotype approach as implemented in the variance component analytical tools. Results: The Arg148Gly variant was found to be monomorphic in our dataset. Of the phenotypes examined for association, the A/C variant located in intron-1 (rs12794795) exhibited statistically significant association only with diastolic blood pressure (p = 0.018) after accounting for the trait-specific covariate effects. The Cys311Ser variant failed to show statistically significant association with any of the phenotypes examined. Conclusion: In conclusion, the variants examined at the PON2 locus in Mexican Americans do not appear to be a major contributor to T2DM, cardiovascular or renal disease risk, although they exhibited a small effect on the blood pressure values.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalKidney and Blood Pressure Research
Volume32
Issue number3
DOIs
StatePublished - Aug 2009

Keywords

  • Association analyses
  • Genetic polymorphisms
  • Mexican Americans
  • PON2
  • Systolic blood pressure

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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