Evaluation of nikkomycin Z with frequent oral administration in an experimental model of central nervous system coccidioidomycosis

Nathan P. Wiederhold, Laura K. Najvar, Rosie Jaramillo, Marcos Olivo, David J. Larwood, Thomas F. Patterson

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the in vivo activity of nikkomycin Z against central nervous system coccidioidomycosis. Mice were inoculated intracranially with arthroconidia of Coccidoides immitis, and treatment with nikkomycin Z (50, 100, or 300 mg/kg orally TID) or fluconazole (25 mg/kg orally BID) began 2 days later. Each dose of nikkomycin Z and fluconazole significantly improved survival and reduced brain fungal burden compared with vehicle control. Further studies of nikkomycin Z against coccidioidomycosis are warranted.

Original languageEnglish (US)
JournalMicrobiology Spectrum
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2024

Keywords

  • Coccidioides species
  • coccidioidomycosis
  • nikkomycin Z

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • General Immunology and Microbiology
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

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