Evaluation of myosin-reactive antibodies from a panel of myasthenia gravis patients

Sumathy Mohan, Richard J. Barohn, Carlayne E. Jackson, Keith A. Krolick

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


In the study described below, 97 myasthenia gravis (MG) patients have been evaluated for antibody reactivity against muscle myosin. With few exceptions, we could clearly observe a positive correlation between the presence of circulating serum anti-myosin antibodies and disease severity. Unlike some studies of anti-striational antibodies in MG patients, no association with thymoma was apparent. Moreover, no relationships were revealed between the severity of disease symptoms demonstrated and absolute anti-myosin antibody titers or prominent IgG subclasses. Therefore, we suggest that expression of myosin reactivity may be one useful parameter for predicting disease severity in those patients, but it is not prerequisite for induction of MG.

Original languageEnglish (US)
Pages (from-to)266-273
Number of pages8
JournalClinical Immunology and Immunopathology
Issue number3
StatePublished - Mar 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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