Evaluation of leukocyte chemotaxis in vitro in thermally injured patients

G. D. Warden, A. D. Mason, B. A. Pruitt

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Leokocyte chemotaxis in vitro was studied by a modification of the Boyden technic in 46 thermally injured patients. All patients demonstrated a decrease in leukocyte migration through a Nuclepore filter toward a standard casein serum chemotactic agent. Leukocyte chemotaxis was inversely correlated with burn size during the first 72 hr after injury. After 72 hr, leukocyte chemotaxis directly correlated with clinical status and was highly predictive for ultimate mortality. Since mortality was largely due to infection, these findings suggest that suppression of leukocyte chemotaxis may explain the susceptibility to opportunistic infection in thermally injured patients.

Original languageEnglish (US)
Pages (from-to)1001-1004
Number of pages4
JournalJournal of Clinical Investigation
Volume54
Issue number4
DOIs
StatePublished - 1974

ASJC Scopus subject areas

  • Medicine(all)

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