Evaluation of enamel matrix derivative as an adjunct to non-surgical periodontal therapy

Mauricio A. Gutierrez, James T. Mellonig, David L. Cochran

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Objectives: The aim of this study was to evaluate the adjunctive use of enamel matrix derivative (EMD) on periodontal healing following nonsurgical periodontal therapy (scaling and root planing - SRP). Material and methods: The study was performed as an intraindividual, longitudinal trial of 3 months duration with a double-blinded, split-mouth, controlled, and randomized design. Twenty-two patients with moderate to severe chronic periodontitis were enrolled in the study. In each patient, two sites with pocket depths ≥ 5 mm and with radiographic angular bone defects > 3 mm were selected. Baseline examination included measurement of probing pocket depth (PPD) and clinical attachment levels (CAL). The presence or absence of plaque and bleeding on probing at selected sites was also recorded. Following initial examination, full-mouth SRP was performed. Study sites were then treated with 24% EDTA for 2 min, followed by thorough irrigation with sterile saline. The sites were then randomized. The experimental site received subgingival application of enamel matrix derivative (Emdogain®, BIORA AB, Malmo, Sweden). The control site received no additional treatment. At 3 months, all sites were re-examined. The response to therapy in experimental and control sites was evaluated, using change in probing depth and CAL as the primary outcome variables. Statistical analysis (paired t-tests) was used to compare response to treatment in control versus experimental sites. Results: Statistically significant changes in PPD and CAL were seen in both treatment groups from baseline to 3 months. The mean PPD reduction was 2.3 ± 0.5 mm for control sites and 2.0 ± 0.3 mm for experimental sites. The mean CAL gain was 1.8 ± 0.4 mm for control sites, and 1.4 ± 0.3 mm for experimental sites. Statistical analysis, however, revealed no significant difference in PPD reduction or CAL gain between experimental and control groups (p > 0.4). In addition, no difference was found between treatment groups in bleeding or plaque indices at 3 months. Conclusion: The findings from the present study do not support the use of EMD during routine, nonsurgical debridement of periodontal pockets as measured 3 months post SRP.

Original languageEnglish (US)
Pages (from-to)739-745
Number of pages7
JournalJournal of Clinical Periodontology
Issue number8
StatePublished - Aug 2003


  • Enamel matrix derivative
  • Nonsurgical periodontal therapy
  • Root planing
  • Scaling

ASJC Scopus subject areas

  • Periodontics


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