Abstract
Drug induced changes in 3H-thymidine fractional incorporation (TFI) in 4 human colonic xenograft lines and mouse gastrointestinal tissues have been related to the growth inhibition and host toxicity respectively. Using the TFI assay, the combinations of actinomycin D with cyclophosphamide and methyl CCNU with pentamethyl-melamine have been examined. Both combinations showed greater than additive activity against only 1 of the 3 xenograft lines in which they were tested. The TFI assay allows more rapid evaluation of drug activity and is more sensitive than growth delay studies. It also allows quantitative measurement of cytotoxic activity in gastrointestinal tissues after sublethal dose levels.
Original language | English (US) |
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Pages (from-to) | 763-769 |
Number of pages | 7 |
Journal | European Journal of Cancer (1965) |
Volume | 15 |
Issue number | 5 |
DOIs | |
State | Published - May 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine