Evaluation of chromosomal damage in males exposed to agent orange and their families

C. I. Kaye, S. Rao, S. J. Simpson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Agent Orange (AO), a phenoxyherbicide, and dioxin, an impurity found in AO, are considered clastogens, mutagens, and teratogens in plants and animals. AO has come under suspicion in humans following claims that it causes chromosome damage and birth defects in offspring of exposed individuals. No well-designed epidemiological studies are available to support this conclusion. Of ten exposed individuals studied for chromosome breaks and sister chromatid exchange frequencies, eight were ascertained because they had children with congenital defects. No consistent pattern of anomalies was observed. Five children had neurologic deficit, one child had a central nervous system anomaly, and one child was affected with glaucoma. Although all individuals studied had normal karyotypes, a statistically significant increase in chromosome breakage was observed in exposed males compared to their unexposed wives and children; sister chromatid exchange frequency was not increased.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalJournal of Craniofacial Genetics and Developmental Biology
Issue numberSUPPL. 1
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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