Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea

Tarcisius Uluk, Waridibo E. Allison, John Vince, Handan Wand, Nakapi Tefuarani, Louise M. Causer, Paulus Ripa, Maylene Kariko, Oscillah Kaminiel, Philip Cunningham, Steve M. Graham, John M. Kaldor

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

There are few data from tuberculosis (TB) endemic settings of the performance and outcome predictors of the QuantiFERON-TB Gold in Tube assay (QFT) in children with suspected TB. A prospective cross-sectional study was conducted in Papua New Guinea children with suspected TB evaluated at Port Moresby General Hospital (Port Moresby, Papua New Guinea). Two hundred sixteen children were enrolled including 106 probable TB, 87 possible TB and 23 without TB. Concordance between QFT and tuberculin skin test results was 86% (P < 0.001, κ = 0.70). QFT was significantly more likely to be positive than tuberculin skin test, overall and within the probable or possible TB categories, with no difference in prevalence of positivity between these 2 categories. The role of QFT in supporting the clinical diagnosis of TB in endemic settings, where resources are limited, remains uncertain especially as cost and technical requirements remain considerable.

Original languageEnglish (US)
Pages (from-to)187-189
Number of pages3
JournalPediatric Infectious Disease Journal
Volume32
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Keywords

  • HIV
  • Papua New Guinea
  • children
  • interferon gamma release assay
  • tuberculin skin test
  • tuberculosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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