TY - JOUR
T1 - Evaluation of a prototype trilayer membrane (PTLM) for lateral ridge augmentation
T2 - An experimental study in the canine mandible
AU - Von Arx, T.
AU - Cochran, D. L.
AU - Schenk, R. K.
AU - Buser, D.
N1 - Funding Information:
The study was funded by grants from Geistlich Söhne AG, Wolhusen, Switzerland, the ITI Foundation for the Promotion of Oral Implantology, Basle, Switzerland, and the Foundation of Dental Research and Education, Waldenburg, Switzerland.
PY - 2002
Y1 - 2002
N2 - The objective of this animal study was to evaluate a biodegradable/bioresorbable prototype trilayer membrane (PTLM) consisting of two collagen layers and an internal polylactide layer for lateral ridge augmentation in conjunction with two different bone grafting materials: particulate autograft or deproteinized bovine bone mineral (DBBM). In four mongrel dogs, two lateral bone defects per side were created in the mandible. The four defects per dog were randomly subjected to the following grafting treatments 3 months later: 1 PTLM + DBBM 2 PTLM + particulate autograft 3 ePTFE membrane + DBBM 4 ePTFE membrane + particulate autograft. After a healing period of 4 1/2 months, the dogs were sacrificed for histological and histomorphometrical analysis. Percentage calculations for areas showing bone regeneration within the former defect outline were 56.8% for PTLM + DBBM, 85.2% for PTLM + autograft, 52.3% for ePTFE + DBBM, and 96.9% for ePTFE + autograft (differences between autograft and DBBM sites were significant at P<0.01 to P<0.05). Measurements of ridge enlargement (horizontal bone gain) were also significantly better for autograft+ePTFE sites compared to the other three grafting treatments. Histology demonstrated for most PTLM sites a moderate infiltration of lymphocytes and plasma cells adjacent to empty spaces corresponding to polylactide fragments. In addition, these reactions appeared to provoke subsequent resorption of newly formed bone. No such findings were seen in ePTFE sites. The tested prototype membrane cannot be recommended for clinical application.
AB - The objective of this animal study was to evaluate a biodegradable/bioresorbable prototype trilayer membrane (PTLM) consisting of two collagen layers and an internal polylactide layer for lateral ridge augmentation in conjunction with two different bone grafting materials: particulate autograft or deproteinized bovine bone mineral (DBBM). In four mongrel dogs, two lateral bone defects per side were created in the mandible. The four defects per dog were randomly subjected to the following grafting treatments 3 months later: 1 PTLM + DBBM 2 PTLM + particulate autograft 3 ePTFE membrane + DBBM 4 ePTFE membrane + particulate autograft. After a healing period of 4 1/2 months, the dogs were sacrificed for histological and histomorphometrical analysis. Percentage calculations for areas showing bone regeneration within the former defect outline were 56.8% for PTLM + DBBM, 85.2% for PTLM + autograft, 52.3% for ePTFE + DBBM, and 96.9% for ePTFE + autograft (differences between autograft and DBBM sites were significant at P<0.01 to P<0.05). Measurements of ridge enlargement (horizontal bone gain) were also significantly better for autograft+ePTFE sites compared to the other three grafting treatments. Histology demonstrated for most PTLM sites a moderate infiltration of lymphocytes and plasma cells adjacent to empty spaces corresponding to polylactide fragments. In addition, these reactions appeared to provoke subsequent resorption of newly formed bone. No such findings were seen in ePTFE sites. The tested prototype membrane cannot be recommended for clinical application.
KW - Autogenous bone graft
KW - Collagen-polylactide membrane
KW - Deproteinized bovine bone mineral
KW - Experimental dog study
KW - Guided bone regeneration
KW - Lateral ridge augmentation
KW - ePTFE membrane
UR - http://www.scopus.com/inward/record.url?scp=0035983692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035983692&partnerID=8YFLogxK
U2 - 10.1054/ijom.2001.0205
DO - 10.1054/ijom.2001.0205
M3 - Article
C2 - 12102419
AN - SCOPUS:0035983692
SN - 0901-5027
VL - 31
SP - 190
EP - 199
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 2
ER -