Evaluation and management of patients with inhalation injury

Basil A Pruitt, W. G. Cioffi, T. Shimazu, H. Ikeuchi, A. D. Mason

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Inhalation injury, present in approximately one third of burned patients treated at burn centers, increases mortality by a maximum of 20% in relation to age and extent of burn. The development of animal models of inhalation injury has made possible the identification of both the airway and vascular responses evoked by smoke inhalation. Inflammatory occlusion of terminal bronchioles and necrosis of the endobronchial mucosa render the airway and pulmonary parenchyma susceptible to infection and the resulting pneumonitis further increases mortality. Early diagnosis, best achieved by endoscopic bronchoscopy and 133xenon ventilation perfusion scan, permits timely application of high-frequency ventilation that appears to reduce the incidence of pneumonia and to decrease mortality. Pharmacologic agents give promise of ameliorating the deleterious changes of the vasculature. The recent advances in understanding inhalation injury have identified the research needed to further improve patient salvage.

Original languageEnglish (US)
JournalJournal of Trauma
Volume30
Issue number12 SUPPL.
StatePublished - 1990

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Inhalation
Wounds and Injuries
Mortality
Pneumonia
High-Frequency Ventilation
Bronchioles
Burn Units
Bronchoscopy
Smoke
Blood Vessels
Ventilation
Early Diagnosis
Mucous Membrane
Necrosis
Animal Models
Perfusion
Lung
Incidence
Infection
Research

ASJC Scopus subject areas

  • Surgery

Cite this

Pruitt, B. A., Cioffi, W. G., Shimazu, T., Ikeuchi, H., & Mason, A. D. (1990). Evaluation and management of patients with inhalation injury. Journal of Trauma, 30(12 SUPPL.).

Evaluation and management of patients with inhalation injury. / Pruitt, Basil A; Cioffi, W. G.; Shimazu, T.; Ikeuchi, H.; Mason, A. D.

In: Journal of Trauma, Vol. 30, No. 12 SUPPL., 1990.

Research output: Contribution to journalArticle

Pruitt, BA, Cioffi, WG, Shimazu, T, Ikeuchi, H & Mason, AD 1990, 'Evaluation and management of patients with inhalation injury', Journal of Trauma, vol. 30, no. 12 SUPPL..
Pruitt BA, Cioffi WG, Shimazu T, Ikeuchi H, Mason AD. Evaluation and management of patients with inhalation injury. Journal of Trauma. 1990;30(12 SUPPL.).
Pruitt, Basil A ; Cioffi, W. G. ; Shimazu, T. ; Ikeuchi, H. ; Mason, A. D. / Evaluation and management of patients with inhalation injury. In: Journal of Trauma. 1990 ; Vol. 30, No. 12 SUPPL.
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