Evaluating mitochondrial DNA in cancer occurrence and development

Lijun Shen, Hezhi Fang, Tao Chen, Jing He, Mei Zhang, Xiaosong Wei, Yijuan Xin, Yulin Jiang, Zhinan Ding, Jingzhang Ji, Jianxin Lu, Yidong Bai

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Abnormal mitochondria have long been hypothesized to be involved in tumorigenesis. Mitochondrial DNA (mtDNA) mutations have been found in various cancer cells, yet their role in tumorigenesis remains largely unknown. Our long-term goal is to understand the role of mtDNA polymorphism and mtDNA mutations in tumorigenesis. We focused on the role of the mtDNA haplogroup; a 4,977 bp common mtDNA deletion; mtDNA mutations in the main control region of mtDNA or displacement loop; and mtDNA heteroplasmy in cancer occurrence and cancer development. Our results indicate that qualitative and quantitative changes in mtDNA play an important role in cancer development.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1201
DOIs
StatePublished - Jul 2010

Keywords

  • D-Loop region
  • cancer
  • common deletion
  • copy number
  • heteroplasmy
  • mitochondrial DNA mutation
  • mitochondrial haplogroup

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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