Etiology of infertility in monkeys with endometriosis

Luteinized unruptured follicles, luteal phase defects, pelvic adhesions, and spontaneous abortions

Robert S Schenken, R. H. Asch, R. F. Williams, G. D. Hodgen

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

To elucidate the etiology of infertility due to endometriosis, we autografted endometrial or adipose tissue to the pelvic peritoneum of 21 cynomolgus monkeys. These primates were divided into five groups: control animals with adipose tissue autografts (n = 5), animals with microscopic endometriosis (n = 5), animals with mild endometriosis (n = 5), animals with moderate endometriosis (n = 4), and animals with severe endometriosis (n = 2). During three subsequent menstrual cycles, each animal underwent (1) serial assay of peripheral serum gonadotrophins and steroids; (2) mating timed according to daily serum 17β-estradiol; and (3) laparotomy to document an ovulatory stigma. The chemical and term pregnancy rates were lower among monkeys with moderate or severe endometriosis, as compared with control animals. The impaired fertility in monkeys with endometriosis appeared to be mediated primarily by failure of follicular rupture and/or pelvic adhesions.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalFertility and Sterility
Volume41
Issue number1
StatePublished - 1984

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Luteal Phase
Spontaneous Abortion
Endometriosis
Infertility
Haplorhini
Adipose Tissue
Macaca fascicularis
Peritoneum
Autografts
Pregnancy Rate
Menstrual Cycle
Serum
Gonadotropins
Laparotomy
Primates
Fertility
Rupture
Estradiol
Steroids
Control Groups

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Etiology of infertility in monkeys with endometriosis : Luteinized unruptured follicles, luteal phase defects, pelvic adhesions, and spontaneous abortions. / Schenken, Robert S; Asch, R. H.; Williams, R. F.; Hodgen, G. D.

In: Fertility and Sterility, Vol. 41, No. 1, 1984, p. 122-130.

Research output: Contribution to journalArticle

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