Abstract
We have employed structural equation models to explicitly distinguish functional status, and therefore 'dementia-relevant' variance in cognitive task performance (i.e., 'δ'). We previously associated δ with cytokines and other serum biomarkers in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. However, that δ homolog did not exhibit factor equivalence across ethnicity. In this study, we construct a δ homolog that exhibits mean and factor equivalence across ethnicity [i.e., 'd(=)']. d(=) is associated significantly with ten of the twelve previously selected biomarkers. Most of these associations are again specific to Non-Hispanic White participants. These findings have yet to be validated in other cohorts, but may suggest cross-ethnic differences in dementia's pathobiological mechanisms between Hispanic Mexican-Americans and Non-Hispanic Whites.
Original language | English (US) |
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Pages (from-to) | 275-287 |
Number of pages | 13 |
Journal | Journal of Alzheimer's Disease |
Volume | 43 |
Issue number | 1 |
DOIs | |
State | Published - 2014 |
Keywords
- Aging
- Hispanic
- cognition
- dementia
- functional status
- g
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health