Ethnicity moderates dementia's biomarkers

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We have employed structural equation models to explicitly distinguish functional status, and therefore 'dementia-relevant' variance in cognitive task performance (i.e., 'δ'). We previously associated δ with cytokines and other serum biomarkers in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. However, that δ homolog did not exhibit factor equivalence across ethnicity. In this study, we construct a δ homolog that exhibits mean and factor equivalence across ethnicity [i.e., 'd(=)']. d(=) is associated significantly with ten of the twelve previously selected biomarkers. Most of these associations are again specific to Non-Hispanic White participants. These findings have yet to be validated in other cohorts, but may suggest cross-ethnic differences in dementia's pathobiological mechanisms between Hispanic Mexican-Americans and Non-Hispanic Whites.

Original languageEnglish (US)
Pages (from-to)275-287
Number of pages13
JournalJournal of Alzheimer's Disease
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Aging
  • Hispanic
  • cognition
  • dementia
  • functional status
  • g

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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