Ethanol enhancement of GABA-induced 36Cl- influx does not involve changes in Ca2+

Ashok K. Mehta, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effect of changes in intracellular Ca2+ on ethanol enhancement of GABA-mediated 36Cl- influx was investigated in mammalian cortical neurons in culture. Ethanol potentiated the effect of submaximal concentrations of GABA on the 36Cl- influx, and at 50 mM ethanol directly activated 36Cl- influx in these neurons. Pretreatment of the neurons with dantrolene (an agent that depletes intracellular Ca2+) and the Ca2+ ionophore, A 23187, did not alter the effect of GABA or ethanol enhancement of GABA-mediated 36Cl- influx. Together, these results suggest that changes in intracellular Ca2+ are not involved in ethanol modulation of GABAAergic responses in cortical neurons.

Original languageEnglish (US)
Pages (from-to)355-357
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume47
Issue number2
DOIs
StatePublished - Feb 1994

Keywords

  • Cl influx
  • Ca
  • Cortical neurons
  • Ethanol
  • GABA receptor complex

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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