Ethanol effects on multiple fixed-interval, fixed-ratio responding in mice with deletions of the serotonin transporter gene

Richard J. Lamb, Jonathan W. Pinkston, Lynette C. Daws

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Serotonin transporter knockout (KO) mice self-administer less ethanol than either heterozygous or wild-type mice; however, the mechanistic basis for this difference remains unclear. Here we examine the possibility that ethanol more readily decreases responding in KO mice, thereby limiting ethanol self-administration. To examine whether KO mice were more sensitive to the response-decreasing effects of ethanol, we administered ethanol (0.2-3.2 g/kg) to mice responding under a multiple fixed-ratio 30-response, fixed-interval 300-s schedule of milk presentation. Ethanol decreased responding similarly in all three genotypes. Fixed-ratio responding tended to be decreased at lower doses than fixed-interval responding. The decreased level of ethanol self-administration in serotonin transporter KO mice is not explained by an increased sensitivity to the response-decreasing effects of ethanol in KO mice, as sensitivity to the response-decreasing effects of ethanol was similar in the KO, heterozygous, and wild-type mice.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalBehavioural Pharmacology
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • ethanol
  • mouse
  • operant
  • serotonin transporter

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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