Ethanol effects of pigeons trained to discriminate MK-801, PCP or CGS-19755

E. R. Butelman, S. P. Baron, J. H. Woods

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The non-competitive N-methyl-D-aspartate (NMDA) antagonists MK-801, PCP and ketamine have recently been found to produce full drug-appropriate responding in pigeons trained to ethanol (1.5 g/kg) in a two-key operant drug discrimination procedure. In the present study, ethanol (0.56-3.2 g/kg i.g.) was administered to pigeons trained to discriminate MK-801 (0.18 mg/kg, n = 5), PCP (1.0 mg/kg, n = 4) or the competitive NMDA antagonist CGS-19755 (1.8 mg/kg, n = 4) from vehicle. Up to doses that caused large reductions in response rates, ethanol produced only vehicle-appropriate responding in the pigeons trained to PCP and only low levels of drug-appropriate responding in pigeons trained to MK-801 and CGS-19755. The present results suggest there could be asymmetric generalization between the discriminative stimulus effects of i.g. ethanol and NMDA antagonists.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalBehavioural pharmacology
Volume4
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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