Abstract
The non-competitive N-methyl-D-aspartate (NMDA) antagonists MK-801, PCP and ketamine have recently been found to produce full drug-appropriate responding in pigeons trained to ethanol (1.5 g/kg) in a two-key operant drug discrimination procedure. In the present study, ethanol (0.56-3.2 g/kg i.g.) was administered to pigeons trained to discriminate MK-801 (0.18 mg/kg, n = 5), PCP (1.0 mg/kg, n = 4) or the competitive NMDA antagonist CGS-19755 (1.8 mg/kg, n = 4) from vehicle. Up to doses that caused large reductions in response rates, ethanol produced only vehicle-appropriate responding in the pigeons trained to PCP and only low levels of drug-appropriate responding in pigeons trained to MK-801 and CGS-19755. The present results suggest there could be asymmetric generalization between the discriminative stimulus effects of i.g. ethanol and NMDA antagonists.
Original language | English (US) |
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Pages (from-to) | 57-60 |
Number of pages | 4 |
Journal | Behavioural pharmacology |
Volume | 4 |
Issue number | 1 |
State | Published - Jan 1 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health