Ethanol does not alter the binding of the γ-hydroxybutyric acid (GHB) receptor ligand [3H]NCS-382 in the rat brain

Ashok K. Mehta, Nicole M. Muschaweck, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We investigated the effect of ethanol on the binding of the γ-hydroxybutyric acid (GHB) receptor ligand [3H]NCS-382 in the rat cerebral cortex and hippocampus. Ethanol (50-100 mM) did not alter the binding of [3H]NCS-382. Furthermore, acute (3 g/kg, p.o.) as well as chronic (9-15 g/kg/day p.o. for 6 days) administration of ethanol also did not have any significant effect on the binding of [3H]NCS-382 in the rat cerebrocortical and hippocampal membranes. These observations suggest that ethanol does not interact directly with the GHB receptor in vitro or in vivo, and GHB receptor may not be involved in the pharmacological effects of ethanol.

Original languageEnglish (US)
Pages (from-to)323-325
Number of pages3
JournalDrug and Alcohol Dependence
Volume75
Issue number3
DOIs
StatePublished - Sep 6 2004

Keywords

  • γ-Hydroxybutyric acid receptor
  • Binding
  • Cerebral cortex
  • Ethanol
  • Hippocampus
  • NCS-382

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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