Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors

Matthew J. Wayner; Deborah L. Armstrong; Jodie L. Polan-Curtain; John B. Denny

doi:10.1016/0196-9781(93)90129-5

Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT₁ receptors

Matthew J. Wayner, Deborah L. Armstrong, Jodie L. Polan-Curtain, John B. Denny

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, EtOH, and DZ can be blocked by AII receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT₁ subtype AII receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT₁ receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.

Original language	English (US)
Pages (from-to)	441-444
Number of pages	4
Journal	Peptides
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(93)90129-5
State	Published - 1993

Keywords

Angiotensin II
Diazepam
Ethanol
Granule cells
Hippocampus
Inhibition
Long-term potentiation
Lorsartan
Saralasin

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0196-9781(93)90129-5

Cite this

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title = "Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors",

abstract = "Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, EtOH, and DZ can be blocked by AII receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT1 subtype AII receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT1 receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.",

keywords = "Angiotensin II, Diazepam, Ethanol, Granule cells, Hippocampus, Inhibition, Long-term potentiation, Lorsartan, Saralasin",

author = "Wayner, {Matthew J.} and Armstrong, {Deborah L.} and Polan-Curtain, {Jodie L.} and Denny, {John B.}",

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T1 - Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors

AU - Wayner, Matthew J.

AU - Armstrong, Deborah L.

AU - Polan-Curtain, Jodie L.

AU - Denny, John B.

PY - 1993

Y1 - 1993

N2 - Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, EtOH, and DZ can be blocked by AII receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT1 subtype AII receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT1 receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.

AB - Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, EtOH, and DZ can be blocked by AII receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT1 subtype AII receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT1 receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.

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KW - Diazepam

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KW - Granule cells

KW - Hippocampus

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KW - Long-term potentiation

KW - Lorsartan

KW - Saralasin

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