Estrogen receptors in the temporomandibular joint of the baboon (Papio cynocephalus): An autoradiographic study

Thomas B. Aufdemorte, Joseph E. Van Sickels, M. Franklin Dolwick, Peter J. Sheridan, G. Richard Holt, Steven B. Aragon, George A. Gates

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Using an autoradiographic method, the temporomandibular joint (TMJ) complex of five aged female baboons was studied for the presence of receptors for estradiol-17β. The study was performed in an effort to learn more of the pathophysiology of this joint and in an attempt to provide a scientific basis to explain the reported preponderance of women who seek and undergo treatment for signs and symptoms referable to the TMJ. This experiment revealed that the TMJ complex contains numerous cells with receptors for estrogen, particularly the articular surface of the condyle, articular disk, and capsule. Muscles of mastication contained relatively fewer receptors. As a result, one may postulate a role for the sex steroid hormones in the maintenance, repair, and/or pathogenesis of the TMJ. Additional studies are necessary to fully determine the significance of hormone receptors in this site and any correlation between diseases of the TMJ and the endocrine status of affected patients.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume61
Issue number4
DOIs
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)

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