Estrogen receptor-alpha gene Xbai A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals

Amanda Caroline Silva Chaves; Vanessa Gomes Fraga; Henrique Cerqueira Guimarães; Antonio Lucio Teixeira; Maira Tonidandel Barbosa; Maria das Graças Valho; Ana Paula Lucas Mota; Ieda de Fátima Oliveira Silva; Paulo Caramelli; Karina Braga Gomes; Patrícia Nessralla Alpoim

doi:10.1590/0004-282X20170018

Estrogen receptor-alpha gene Xbai A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals

Amanda Caroline Silva Chaves, Vanessa Gomes Fraga, Henrique Cerqueira Guimarães, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Maria das Graças Valho, Ana Paula Lucas Mota, Ieda de Fátima Oliveira Silva, Paulo Caramelli, Karina Braga Gomes, Patrícia Nessralla Alpoim

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This prospective study aimed to evaluate the influence of the -351A/G XbaI polymorphism in the estrogen receptor-alpha (ESR-1) gene on global cognitive scores of a community sample of healthy oldest-old individuals within one year of follow up. Methods: The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic information. Results: The XbaI -351 AA genotype was more common among cognitive decliners, while -351G allele carriers showed cognitive stability or improvement. Conclusion: These results suggest that ESR-1 could be associated with one-year cognitive decline in healthy oldest-old individuals, since the estrogen pathway may be involved with neuroprotection, even in healthy brain aging.

Original language	English (US)
Pages (from-to)	172-175
Number of pages	4
Journal	Arquivos de neuro-psiquiatria
Volume	75
Issue number	3
DOIs	https://doi.org/10.1590/0004-282X20170018
State	Published - Mar 2017
Externally published	Yes

Keywords

Aging
Cognition
Estrogen receptor alpha
Genetic
Polymorphism

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry

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10.1590/0004-282X20170018

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Chaves, A. C. S., Fraga, V. G., Guimarães, H. C., Teixeira, A. L., Barbosa, M. T., Valho, M. D. G., Mota, A. P. L., Silva, I. D. F. O., Caramelli, P., Gomes, K. B., & Alpoim, P. N. (2017). Estrogen receptor-alpha gene Xbai A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals. Arquivos de neuro-psiquiatria, 75(3), 172-175. https://doi.org/10.1590/0004-282X20170018

Chaves, ACS, Fraga, VG, Guimarães, HC, Teixeira, AL, Barbosa, MT, Valho, MDG, Mota, APL, Silva, IDFO, Caramelli, P, Gomes, KB & Alpoim, PN 2017, 'Estrogen receptor-alpha gene Xbai A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals', Arquivos de neuro-psiquiatria, vol. 75, no. 3, pp. 172-175. https://doi.org/10.1590/0004-282X20170018

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title = "Estrogen receptor-alpha gene Xbai A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals",

abstract = "This prospective study aimed to evaluate the influence of the -351A/G XbaI polymorphism in the estrogen receptor-alpha (ESR-1) gene on global cognitive scores of a community sample of healthy oldest-old individuals within one year of follow up. Methods: The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic information. Results: The XbaI -351 AA genotype was more common among cognitive decliners, while -351G allele carriers showed cognitive stability or improvement. Conclusion: These results suggest that ESR-1 could be associated with one-year cognitive decline in healthy oldest-old individuals, since the estrogen pathway may be involved with neuroprotection, even in healthy brain aging.",

keywords = "Aging, Cognition, Estrogen receptor alpha, Genetic, Polymorphism",

author = "Chaves, {Amanda Caroline Silva} and Fraga, {Vanessa Gomes} and Guimar{\~a}es, {Henrique Cerqueira} and Teixeira, {Antonio Lucio} and Barbosa, {Maira Tonidandel} and Valho, {Maria das Gra{\c c}as} and Mota, {Ana Paula Lucas} and Silva, {Ieda de F{\'a}tima Oliveira} and Paulo Caramelli and Gomes, {Karina Braga} and Alpoim, {Patr{\'i}cia Nessralla}",

year = "2017",

month = mar,

doi = "10.1590/0004-282X20170018",

language = "English (US)",

volume = "75",

pages = "172--175",

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AU - Fraga, Vanessa Gomes

AU - Guimarães, Henrique Cerqueira

AU - Teixeira, Antonio Lucio

AU - Barbosa, Maira Tonidandel

AU - Valho, Maria das Graças

AU - Mota, Ana Paula Lucas

AU - Silva, Ieda de Fátima Oliveira

AU - Caramelli, Paulo

AU - Gomes, Karina Braga

AU - Alpoim, Patrícia Nessralla

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AB - This prospective study aimed to evaluate the influence of the -351A/G XbaI polymorphism in the estrogen receptor-alpha (ESR-1) gene on global cognitive scores of a community sample of healthy oldest-old individuals within one year of follow up. Methods: The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic information. Results: The XbaI -351 AA genotype was more common among cognitive decliners, while -351G allele carriers showed cognitive stability or improvement. Conclusion: These results suggest that ESR-1 could be associated with one-year cognitive decline in healthy oldest-old individuals, since the estrogen pathway may be involved with neuroprotection, even in healthy brain aging.

KW - Aging

KW - Cognition

KW - Estrogen receptor alpha

KW - Genetic

KW - Polymorphism

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Estrogen receptor-alpha gene Xbai A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals

Abstract

Keywords

ASJC Scopus subject areas

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