Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

Roshni D. Thakkar; Ruimin Wang; Gangadhara R. Sareddy; Ratna K. Vadlamudi; Darrell W. Brann

doi:10.1093/oso/9780190645908.003.0024

Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

Roshni D. Thakkar, Ruimin Wang, Gangadhara R. Sareddy, Ratna K. Vadlamudi, Darrell W. Brann

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The steroid hormone 17β-estradiol (E2) is neuroprotective in several neurodegenerative conditions, including cerebral ischemia, traumatic brain injury, and Alzheimer’s disease (AD). This chapter focuses on the evidence supporting a neuroprotective role of E2 in the hippocampus in cerebral ischemia and AD and reviews various mechanisms thought to underlie E2-induced neuroprotection. Specifically, the chapter discusses the mechanistic role of (a) the various estrogen receptor subtypes, (b) genomic versus nongenomic signaling, (c) regulation of the prosurvival Wnt/β−catenin pathway, and (d) anti-inflammatory effects of E2 in the hippocampus. Finally, we also discuss the role of a novel estrogen receptor co-activator protein, proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) in mediating E2 genomic and non-genomic signaling, as well as the neuroprotective and cognitive-enhancing effects of E2 in the hippocampus.

Original language	English (US)
Title of host publication	Estrogens and Memory
Subtitle of host publication	Basic Research and Clinical Implications
Publisher	Oxford University Press
Pages	401-415
Number of pages	15
ISBN (Electronic)	9780190645922
ISBN (Print)	9780190645908
DOIs	https://doi.org/10.1093/oso/9780190645908.003.0024
State	Published - Jan 1 2020

Keywords

Anti-inflammation
Estrogen
Hippocampus
Neuroprotection
Signaling pathways

ASJC Scopus subject areas

General Neuroscience
General Social Sciences

Access to Document

10.1093/oso/9780190645908.003.0024

Cite this

@inbook{84f9a629427a44eba61eb787a3049de1,

title = "Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus",

abstract = "The steroid hormone 17β-estradiol (E2) is neuroprotective in several neurodegenerative conditions, including cerebral ischemia, traumatic brain injury, and Alzheimer{\textquoteright}s disease (AD). This chapter focuses on the evidence supporting a neuroprotective role of E2 in the hippocampus in cerebral ischemia and AD and reviews various mechanisms thought to underlie E2-induced neuroprotection. Specifically, the chapter discusses the mechanistic role of (a) the various estrogen receptor subtypes, (b) genomic versus nongenomic signaling, (c) regulation of the prosurvival Wnt/β−catenin pathway, and (d) anti-inflammatory effects of E2 in the hippocampus. Finally, we also discuss the role of a novel estrogen receptor co-activator protein, proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) in mediating E2 genomic and non-genomic signaling, as well as the neuroprotective and cognitive-enhancing effects of E2 in the hippocampus.",

keywords = "Anti-inflammation, Estrogen, Hippocampus, Neuroprotection, Signaling pathways",

author = "Thakkar, \{Roshni D.\} and Ruimin Wang and Sareddy, \{Gangadhara R.\} and Vadlamudi, \{Ratna K.\} and Brann, \{Darrell W.\}",

year = "2020",

month = jan,

day = "1",

doi = "10.1093/oso/9780190645908.003.0024",

language = "English (US)",

isbn = "9780190645908",

pages = "401--415",

booktitle = "Estrogens and Memory",

publisher = "Oxford University Press",

}

TY - CHAP

T1 - Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

AU - Thakkar, Roshni D.

AU - Wang, Ruimin

AU - Sareddy, Gangadhara R.

AU - Vadlamudi, Ratna K.

AU - Brann, Darrell W.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - The steroid hormone 17β-estradiol (E2) is neuroprotective in several neurodegenerative conditions, including cerebral ischemia, traumatic brain injury, and Alzheimer’s disease (AD). This chapter focuses on the evidence supporting a neuroprotective role of E2 in the hippocampus in cerebral ischemia and AD and reviews various mechanisms thought to underlie E2-induced neuroprotection. Specifically, the chapter discusses the mechanistic role of (a) the various estrogen receptor subtypes, (b) genomic versus nongenomic signaling, (c) regulation of the prosurvival Wnt/β−catenin pathway, and (d) anti-inflammatory effects of E2 in the hippocampus. Finally, we also discuss the role of a novel estrogen receptor co-activator protein, proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) in mediating E2 genomic and non-genomic signaling, as well as the neuroprotective and cognitive-enhancing effects of E2 in the hippocampus.

AB - The steroid hormone 17β-estradiol (E2) is neuroprotective in several neurodegenerative conditions, including cerebral ischemia, traumatic brain injury, and Alzheimer’s disease (AD). This chapter focuses on the evidence supporting a neuroprotective role of E2 in the hippocampus in cerebral ischemia and AD and reviews various mechanisms thought to underlie E2-induced neuroprotection. Specifically, the chapter discusses the mechanistic role of (a) the various estrogen receptor subtypes, (b) genomic versus nongenomic signaling, (c) regulation of the prosurvival Wnt/β−catenin pathway, and (d) anti-inflammatory effects of E2 in the hippocampus. Finally, we also discuss the role of a novel estrogen receptor co-activator protein, proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) in mediating E2 genomic and non-genomic signaling, as well as the neuroprotective and cognitive-enhancing effects of E2 in the hippocampus.

KW - Anti-inflammation

KW - Estrogen

KW - Hippocampus

KW - Neuroprotection

KW - Signaling pathways

UR - https://www.scopus.com/pages/publications/105015929598

UR - https://www.scopus.com/inward/citedby.url?scp=105015929598&partnerID=8YFLogxK

U2 - 10.1093/oso/9780190645908.003.0024

DO - 10.1093/oso/9780190645908.003.0024

M3 - Chapter

AN - SCOPUS:105015929598

SN - 9780190645908

SP - 401

EP - 415

BT - Estrogens and Memory

PB - Oxford University Press

ER -

Estrogen Neuroprotection and Anti-Inflammation Actions in the Hippocampus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this