Estrogen modulates neural-immune interactions through intracellular signaling pathways and antioxidant enzyme activity in the spleen of middle-aged ovariectomized female rats

Prathamesh Kale, Aparna Mohanty, Anushree Patil, Miti Mishra, Uday P. Pratap, Hannah P. Priyanka, Srinivasan ThyagaRajan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Modulation of neural-immune interactions by estrogen in the spleens of ovariectomized (OVX) middle-aged female rats was examined. Con A-induced lymphoproliferation, splenic tyrosine hydroxylase (TH) and nerve growth factor (NGF) expression, levels of p-ERK 1/2, p-CREB, and p-Akt, and activity of superoxide dismutase decreased in OVX rats while estrogen treatment enhanced their expression, levels, and activity. Also, estrogen treatment enhanced Con A-induced IFN-γ production and decreased Con A-induced IL-2 production compared to OVX animals. In contrast, estrogen increased the extent of lipid peroxidation and protein carbonyl formation while OVX induced a decline in protein carbonyl formation. These results suggest that estrogen enhances neural-immune interactions while simultaneously affecting it through generation of free radicals as reflected by increased lipid peroxidation and protein carbonyl formation.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalJournal of Neuroimmunology
Volume267
Issue number1-2
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Akt
  • CREB
  • Cytokine
  • ERK
  • Nerve growth factor
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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