Estrogen-induced pial arteriolar dilation is prostanoid associated in the newborn

S. Zuckerman, M. Son, J. R. Haywood

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Estrogens have vascular protective effects in addition to their anti-lipid effects, Estrogens enhance endothelium-dependent vasodilation in the adult. While estrogens increase constitutive nitric oxide (NO) synthase activity, NO does not have a major role in maintenance of vasomotor tone in the newborn. We hypothesized that if estrogens altered vascular tone in the newborn, it would be via a dilator system other than NO. Using the closed cranial window technique, pial arterial vessel diameter was quantified in response to topically administered ovarian steroids in piglets anesthetized with α-chloralose. 17β-estradiol (10 -5M) produced pial vasodilation that was not altered by topical LNA(10 -3M) and was attenuated by indomethacin (5mg/kg iv): 36.1±1.6% vs 27.3±6.1% vs 6.4±2.6% respectively. 17α-estradiol (10 -5M) produced pial vasodilation that was not altered by topical LNA and was attenuated by indomethacin: 34.6±2.2% vs 26.2±4.2% vs 3.3±4.2% respectively. Carbacyclin(6·10M -11), a prostacyclin analogue in a concentration not sufficient to alter pial diameter, was able to restore the dilator response to β-estradiol attenuated by indomethacin. We conclude that in the newborn the estradiols produce a prostanoid associated pial vasodilation with no major role for NO, and that the prostanoids play a permissive role in the response.

Original languageEnglish (US)
Pages (from-to)A21
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Estrogen-induced pial arteriolar dilation is prostanoid associated in the newborn'. Together they form a unique fingerprint.

Cite this