Estrogen effects on 5-HT1A receptors in hippocampal membranes from ovariectomized rats: functional and binding studies

William P. Clarke, Saul Maayani

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Chronic treatment (4 days) of ovariectomized rats with estrogen produced a two-fold shift to left (with no change in the maximal percent inhibition) in the concentration response curve for the inhibition of adenylyl cyclase activity by 5-HT, but did not alter curves for R-PIA (adenosine A1 agonist) or Gpp(NH)p (to activate Gi). Furthermore, estrogen treatment had no effect on the number or affinity of 5-HT1A binding sites labeled with [3H]8-OH-DPAT. These data, when considered with the results of previous studies, suggest that estrogen treatment may selectively enhance 5-HT1A-mediated responses in rat hippocampus.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalBrain Research
Volume518
Issue number1-2
DOIs
StatePublished - Jun 4 1990
Externally publishedYes

Keywords

  • 8-Hydroxy-2-(di-n-propylamine)tetralin
  • Adenosine A
  • Adenylyl cyclase
  • Female
  • Guanosine 5′-(β,γ-imino)triphosphate
  • Guanosine 5′-triphosphate-binding protein
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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