Abstract
We compared the relative contribution to estimating survival after AIDS diagnosis of a clinical severity measure, the Severity Index for Adults with AIDS (SIAA), and laboratory values at AIDS diagnosis that are often used prognostically. Three SIAA categories were defined from the first AIDS defining condition and the most severe complication within 3 months. We studied 421 Italian patients surviving ≥ 3 months after AIDS diagnosis. Survival curves for laboratory measures grouped by quartile showed poorest survival for CD4 count < 100/μl, hemoglobin < 8 g/dl, total lymphocyte count < 400/μl, and albumin < 3 g/dl. Adjusting for demographics and zidovudine therapy, the estimated hazard of death was 2.4 (95% CI, 1.6-3.5) for CD4 counts < 100/μl versus higher counts and 4.9 (95% CI, 3.0-7.8) for the most versus the least severe SIAA category. SIAA offered greater prognostic discrimination than CD4 count at AIDS diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-65 |
| Number of pages | 7 |
| Journal | Journal of Clinical Epidemiology |
| Volume | 49 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1996 |
| Externally published | Yes |
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Keywords
- AIDS-complications
- AIDS-epidemiology
- AIDS-mortality
- CD4-positive T-lymphocytes
- Severity of illness index
- Survival analysis
ASJC Scopus subject areas
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Epidemiology
Cite this
Estimation of survival after AIDS diagnosis : CD4 T lymphocyte count versus clinical severity. / Turner, Barbara J.; Markson, Leona; Taroni, Francesco.
In: Journal of Clinical Epidemiology, Vol. 49, No. 1, 01.1996, p. 59-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estimation of survival after AIDS diagnosis
T2 - CD4 T lymphocyte count versus clinical severity
AU - Turner, Barbara J.
AU - Markson, Leona
AU - Taroni, Francesco
PY - 1996/1
Y1 - 1996/1
N2 - We compared the relative contribution to estimating survival after AIDS diagnosis of a clinical severity measure, the Severity Index for Adults with AIDS (SIAA), and laboratory values at AIDS diagnosis that are often used prognostically. Three SIAA categories were defined from the first AIDS defining condition and the most severe complication within 3 months. We studied 421 Italian patients surviving ≥ 3 months after AIDS diagnosis. Survival curves for laboratory measures grouped by quartile showed poorest survival for CD4 count < 100/μl, hemoglobin < 8 g/dl, total lymphocyte count < 400/μl, and albumin < 3 g/dl. Adjusting for demographics and zidovudine therapy, the estimated hazard of death was 2.4 (95% CI, 1.6-3.5) for CD4 counts < 100/μl versus higher counts and 4.9 (95% CI, 3.0-7.8) for the most versus the least severe SIAA category. SIAA offered greater prognostic discrimination than CD4 count at AIDS diagnosis.
AB - We compared the relative contribution to estimating survival after AIDS diagnosis of a clinical severity measure, the Severity Index for Adults with AIDS (SIAA), and laboratory values at AIDS diagnosis that are often used prognostically. Three SIAA categories were defined from the first AIDS defining condition and the most severe complication within 3 months. We studied 421 Italian patients surviving ≥ 3 months after AIDS diagnosis. Survival curves for laboratory measures grouped by quartile showed poorest survival for CD4 count < 100/μl, hemoglobin < 8 g/dl, total lymphocyte count < 400/μl, and albumin < 3 g/dl. Adjusting for demographics and zidovudine therapy, the estimated hazard of death was 2.4 (95% CI, 1.6-3.5) for CD4 counts < 100/μl versus higher counts and 4.9 (95% CI, 3.0-7.8) for the most versus the least severe SIAA category. SIAA offered greater prognostic discrimination than CD4 count at AIDS diagnosis.
KW - AIDS-complications
KW - AIDS-epidemiology
KW - AIDS-mortality
KW - CD4-positive T-lymphocytes
KW - Severity of illness index
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=0029970391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029970391&partnerID=8YFLogxK
U2 - 10.1016/0895-4356(95)00067-4
DO - 10.1016/0895-4356(95)00067-4
M3 - Article
C2 - 8598512
AN - SCOPUS:0029970391
VL - 49
SP - 59
EP - 65
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
IS - 1
ER -