Estimating the additive genetic effect of the X chromosome

Jack W. Kent, Thomas D. Dyer, John Blangero

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    We propose a method for efficient estimation of the additive genetic effect of the X chromosome with explicit modeling of eutherian-type dosage compensation. The theoretical derivation of the variance-components model for X-linked loci is reviewed in detail. We develop a model of dosage compensation that allows for both incomplete and heterogeneous lyonization, the existence of which is suggested by recent expression studies. Modeling this relationship, especially in the limit cases of complete or absent compensation, allows estimation of the X effect as a single parameter for ease of comparison to other sources of variance. We present simulation studies to estimate the power and computational efficiency of our proposed method.

    Original languageEnglish (US)
    Pages (from-to)377-388
    Number of pages12
    JournalGenetic epidemiology
    Volume29
    Issue number4
    DOIs
    StatePublished - Dec 1 2005

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    Keywords

    • Dosage compensation
    • Quantitative trait
    • Sex linkage
    • Statistical genetics
    • Variance components
    • X-chromosome

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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