Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand

J. L. Pirkle, W. H. Wolfe, D. G. Patterson, L. L. Needham, J. E. Michalek, J. C. Miner, M. R. Peterson, D. L. Phillips

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD; commonly known as dioxin) in serum has been measured in 36 Air Force Vietnam veterans of Operation Ranch Hand, which was the operation that aerially sprayed the herbicide Agent Orange in Vietnam. From serum specimens taken in 1982 and 1987, the median half-life of 2,3,7,8-TCDD in these Ranch Hand veterans was found to be 7.1 yr (95% confidence interval about the median of 5.8-9.6 yr). These veterans reported no civilian exposure to dioxin or herbicides. Concentrations of 2,3,7,8-TCDD in the 1982 serum specimens from these veterans ranged from 16.9 to 423 parts per trillion on a lipid weight basis. The half-life estimates were not associated with the concentration of 2,3,7,8-TCDD in the 1982 serum specimens. This half-life of 7.1 yr is much longer than the half-life of 2,3,7,8-TCDD reported in animals but is consistent with recent evidence from other human exposures to 2,3,7,8-TCDD.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalJournal of Toxicology and Environmental Health
Volume27
Issue number2
StatePublished - 1989

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Dioxins
Vietnam
Herbicides
Veterans
Half-Life
Hand
Lipids
Animals
Serum
Air
Polychlorinated Dibenzodioxins
1,4-dioxin
Confidence Intervals
Weights and Measures
Agent Orange

ASJC Scopus subject areas

  • Toxicology
  • Pollution

Cite this

Pirkle, J. L., Wolfe, W. H., Patterson, D. G., Needham, L. L., Michalek, J. E., Miner, J. C., ... Phillips, D. L. (1989). Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand. Journal of Toxicology and Environmental Health, 27(2), 165-171.

Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand. / Pirkle, J. L.; Wolfe, W. H.; Patterson, D. G.; Needham, L. L.; Michalek, J. E.; Miner, J. C.; Peterson, M. R.; Phillips, D. L.

In: Journal of Toxicology and Environmental Health, Vol. 27, No. 2, 1989, p. 165-171.

Research output: Contribution to journalArticle

Pirkle, JL, Wolfe, WH, Patterson, DG, Needham, LL, Michalek, JE, Miner, JC, Peterson, MR & Phillips, DL 1989, 'Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand', Journal of Toxicology and Environmental Health, vol. 27, no. 2, pp. 165-171.
Pirkle, J. L. ; Wolfe, W. H. ; Patterson, D. G. ; Needham, L. L. ; Michalek, J. E. ; Miner, J. C. ; Peterson, M. R. ; Phillips, D. L. / Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand. In: Journal of Toxicology and Environmental Health. 1989 ; Vol. 27, No. 2. pp. 165-171.
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