Establishment of human colon carcinoma lines in nude mice

J. Fogh, T. Orfeo, J. Tiso, F. E. Sharkey

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30 Scopus citations


After subcutaneous inoculation into nude mice of 24 human colon adenocarcinomas, growth, defined as histopathologically confirmed tumor growth which has been passed, was observed in 13 cases (54%). Tumors from metastatic sites showed higher take rates (58%) than tumors from primary sites or recurrent tumors (50%). Nine continuous tumor lines were established (69% of growing tumors) with metastatic tumors establishing more readily (100% of growing tumors) than primary tumors (40%). The average period in primary transplant was shorter for metastasis (8.3 wk), than for primary tumors (18.5 wk); total material 10.6 wk. Average periods between passages were shorter than primary transplant times; these periods were shorter for metastases (6.6 wk) than for primary tumors (9.4 wk); total material 7.4 wk. Of 4 growing tumors not established as continuous lines, 3 were primary and 1 a recurrent tumor, and the loss of tumor growth occurred in very early passages, not later than passage 3. All nude mouse-grown colon tumors were moderately well differentiated.

Original languageEnglish (US)
Pages (from-to)136-144
Number of pages9
JournalExperimental Cell Biology
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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