Abstract
Little is known about how diversified retinal ganglion cell (RGC) subtypes develop. Using genetic and electrophysiological analyses, Kiyama et al. identify Tbr1 expression in two types of morphologically and functionally distinct OFF RGCs. Loss-of-function and gain-of-function studies show Tbr1 regulates the formation and dendritic morphogenesis of these cells.
Original language | English (US) |
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Pages (from-to) | 900-915.e5 |
Journal | Cell Reports |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - Apr 16 2019 |
Externally published | Yes |
Keywords
- J-RGC
- Jam2
- OFF RGC
- OFF-sustained RGC
- RGC development
- RGC subtype
- Tbr1
- dendritic branching
- dendritic morphogenesis
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology