Essential fatty acid deficiency in red cells after thermal injury: correction with intravenous fat therapy

G. M. Helmkamp, D. W. Wilmore, A. A. Johnson, Basil A Pruitt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Significant reduction in the levels of linoleate, arachidonate, and docosahexaenoate in red cell membrane phospholipid is described in five severely burned humans. With these decreases in essential polyunsaturated fatty acids there were concomitant increases in palmitate, oleate, and the 24 carbon species. Infusion of a soybean lipid emulsion corrected the imbalance of red cell lipid components in two patients, whereas a fat free intravenous diet that provided comparable calories failed to restore to normal the altered fatty acid pattern of a third individual. In a fourth patient, oral feedings, high in essential fat, resulted in a rapid return to normal fatty acid distribution. Two nonburned patients with enterocutaneous fistulae receiving fat free parenteral nutrition for 1 mth or longer did not demonstrate significant alterations in red cell phospholipid fatty acids. With the restoration of normal fatty acid patterns, the abnormally low membrane lipid phosphorus levels and altered distribution of phospholipids also returned to within normal limits. The infusion of fat emulsion was without major consequence to the fatty acid composition of various plasma lipids.

Original languageEnglish (US)
Pages (from-to)1331-1338
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume26
Issue number12
StatePublished - 1973

Fingerprint

heat injury
Essential Fatty Acids
essential fatty acids
Fatty Acids
Hot Temperature
Fats
therapeutics
Wounds and Injuries
lipids
Phospholipids
Emulsions
Lipids
cells
fatty acids
Intestinal Fistula
Therapeutics
emulsions
Fat-Restricted Diet
phospholipids
Docosahexaenoic Acids

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Helmkamp, G. M., Wilmore, D. W., Johnson, A. A., & Pruitt, B. A. (1973). Essential fatty acid deficiency in red cells after thermal injury: correction with intravenous fat therapy. American Journal of Clinical Nutrition, 26(12), 1331-1338.

Essential fatty acid deficiency in red cells after thermal injury : correction with intravenous fat therapy. / Helmkamp, G. M.; Wilmore, D. W.; Johnson, A. A.; Pruitt, Basil A.

In: American Journal of Clinical Nutrition, Vol. 26, No. 12, 1973, p. 1331-1338.

Research output: Contribution to journalArticle

Helmkamp, G. M. ; Wilmore, D. W. ; Johnson, A. A. ; Pruitt, Basil A. / Essential fatty acid deficiency in red cells after thermal injury : correction with intravenous fat therapy. In: American Journal of Clinical Nutrition. 1973 ; Vol. 26, No. 12. pp. 1331-1338.
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