ESource for standardized health information exchange in clinical research: A systematic review

Maryam Garza, Sahiti Myneni, Amy Nordo, Eric L. Eisenstein, W. Ed Hammond, Anita Walden, Meredith Zozus

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations


The availability of research and outcomes data is the primary limitation to evidence-based practice. Today, only a fraction of clinical decisions are based upon evidence derived from randomized control trials (RCTs), the gold-standard of knowledge discovery. At the same time, clinical trial complexity has steadily increased as has the effort required at clinical investigational sites. Direct use of electronic health record (EHR) data for clinical trials has the potential to address some of these needs, improving data quality and reducing cost.

Original languageEnglish (US)
Title of host publicationImproving Usability, Safety and Patient Outcomes with Health Information Technology
Subtitle of host publicationFrom Research to Practice
EditorsAlex Mu-Hsing Kuo, Andre Kushniruk, Francis Lau, Elizabeth M. Borycki, Gerry Bliss, Helen Monkman, Abdul Vahabpour Roudsari, John A. Bartle-Clar, Karen L. Courtney
PublisherIOS Press
Number of pages10
ISBN (Electronic)9781614999508
StatePublished - 2019
Externally publishedYes

Publication series

NameStudies in Health Technology and Informatics
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365


  • clinical research
  • eSource
  • electronic health records
  • secondary data use

ASJC Scopus subject areas

  • Health Information Management
  • Health Informatics
  • Biomedical Engineering


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