Escape of human immunodeficiency virus type 1 from broadly neutralizing antibodies is not associated with a reduction of viral replicative capacity in vitro

Esther D. Quakkelaar, Evelien M. Bunnik, Floris P.J. van Alphen, Brigitte D.M. Boeser-Nunnink, Ad C. van Nuenen, Hanneke Schuitemaker

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Although the majority of primary HIV-1 variants can be neutralized by broadly neutralizing antibodies such as b12, 2G12, 2F5 and 4E10, resistance to these antibodies has been reported as well. The ability of the broadly neutralizing antibodies to inhibit a variety of viruses suggests that their epitopes are conserved and escape from these antibodies may thus come at a cost to viral fitness. Here we demonstrate that resistance to broadly neutralizing antibodies was in general not associated with a reduced replicative capacity of the virus in vitro. This indicates that loss of replicative capacity due to escape from broadly neutralizing antibodies may be limited.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalVirology
Volume363
Issue number2
DOIs
StatePublished - Jul 5 2007
Externally publishedYes

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Keywords

  • Broadly neutralizing antibodies
  • Escape
  • HIV-1
  • Replicative capacity

ASJC Scopus subject areas

  • Virology

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