Erythropoietin and the Erythropoietin Receptor Are Expressed by Papillary Thyroid Carcinoma from Children and Adolescents. Expression of Erythropoietin Receptor Might Be a Favorable Prognostic Indicator

Thomas G. Eccles, Aneeta Patel, Ajay Verma, Diarmuid Nicholson, Yvonne Lukes, R. Michael Tuttle, Gary L. Francis

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Erythropoietin (EPO) and the EPO receptor (EPO-R) have been implicated in solid tumors of the brain, breast, kidney and female genital tract. Based on their expression by a variety of tumors, we hypothesized that EPO and/or EPO-R might be expressed by thyroid cancers. To test this, we determined EPO and EPO-R expression by immunohistochemistry in 17 papillary thyroid carcinomas (PTC) from children and adolescents. Only a minority of PTC (4/17, 24%) expressed EPO, and there were no significant differences between the PTC that did or did not express EPO. In contrast, EPO-R was detected in the majority of PTC (11/17, 65%). The average tumor size (1.5 ± 0.8 cm), MACIS score (3. 6 ± 0.2) and risk of recurrence (0/11) for the EPO-R(+) PTC were significantly less than those for PTC that failed to express EPO-R (average tumor size = 3.6 ± 2.4 cm, p = 0.021; average MACIS score = 4.3 ± 0.7, p = 0.004; recurrence = 3/6, p = 0.029). We conclude that the majority of PTC from children and adolescents express EPO-R, a finding associated with favorable prognostic indicators and a lower risk of recurrence.

Original languageEnglish (US)
Pages (from-to)411-422
Number of pages12
JournalAnnals of Clinical and Laboratory Science
Volume33
Issue number4
StatePublished - Sep 1 2003
Externally publishedYes

Keywords

  • Cancer
  • Erythropoietin
  • Erythropoietin receptor
  • Thyroid

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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