Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Laurence Morel

doi:10.1016/j.it.2021.10.010

Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Laurence Morel

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.

Original language	English (US)
Pages (from-to)	1054-1056
Number of pages	3
Journal	Trends in Immunology
Volume	42
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2021.10.010
State	Published - Dec 2021
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.it.2021.10.010

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title = "Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus",

abstract = "Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.",

author = "Laurence Morel",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = dec,

doi = "10.1016/j.it.2021.10.010",

language = "English (US)",

volume = "42",

pages = "1054--1056",

journal = "Trends in Immunology",

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TY - JOUR

T1 - Erythrocyte-derived mitochondria

T2 - an unexpected interferon inducer in lupus

AU - Morel, Laurence

PY - 2021/12

Y1 - 2021/12

N2 - Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.

AB - Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.

UR - https://www.scopus.com/pages/publications/85118882377

UR - https://www.scopus.com/pages/publications/85118882377#tab=citedBy

U2 - 10.1016/j.it.2021.10.010

DO - 10.1016/j.it.2021.10.010

M3 - Short survey

C2 - 34764015

AN - SCOPUS:85118882377

SN - 1471-4906

VL - 42

SP - 1054

EP - 1056

JO - Trends in Immunology

JF - Trends in Immunology

IS - 12

ER -

Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Abstract

ASJC Scopus subject areas

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