Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.

Original languageEnglish (US)
Pages (from-to)1054-1056
Number of pages3
JournalTrends in Immunology
Issue number12
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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