Abstract
Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.
Original language | English (US) |
---|---|
Pages (from-to) | 1054-1056 |
Number of pages | 3 |
Journal | Trends in Immunology |
Volume | 42 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2021 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology