Erythrocyte concentrations of the lithium ion: Clinical correlates and mechanisms of action

Alan Frazer, J. Mendels, D. Brunswick, J. London, M. Pring, T. A. Ramsey, J. Rybakowski

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

When lithium carbonate is administered to individuals, there is considerable intersubject variation in the extent of accumulation of Li + by erythrocytes. The primary reason for this is differences in the activity of a Li +-Na + counterflow system, which, under clinical conditions, removes Li + from the cell. It appears that some bipolar patients accumulate more Li + in their red cells than either unipolar depressives or normal controls. The precise clinical characteristics of the bipolar patients who accumulate relatively large amounts of erythrocyte Li + need to be clarified in future research. Finally, the measurement of red cell concentrations of Li + in addition to the usual plasma measurement, can be used as an indicator of patient compliance.

Original languageEnglish (US)
Pages (from-to)1065-1069
Number of pages5
JournalAmerican Journal of Psychiatry
Volume135
Issue number9
StatePublished - 1978
Externally publishedYes

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Lithium
Erythrocytes
Ions
Lithium Carbonate
Patient Compliance

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Frazer, A., Mendels, J., Brunswick, D., London, J., Pring, M., Ramsey, T. A., & Rybakowski, J. (1978). Erythrocyte concentrations of the lithium ion: Clinical correlates and mechanisms of action. American Journal of Psychiatry, 135(9), 1065-1069.

Erythrocyte concentrations of the lithium ion : Clinical correlates and mechanisms of action. / Frazer, Alan; Mendels, J.; Brunswick, D.; London, J.; Pring, M.; Ramsey, T. A.; Rybakowski, J.

In: American Journal of Psychiatry, Vol. 135, No. 9, 1978, p. 1065-1069.

Research output: Contribution to journalArticle

Frazer, A, Mendels, J, Brunswick, D, London, J, Pring, M, Ramsey, TA & Rybakowski, J 1978, 'Erythrocyte concentrations of the lithium ion: Clinical correlates and mechanisms of action', American Journal of Psychiatry, vol. 135, no. 9, pp. 1065-1069.
Frazer A, Mendels J, Brunswick D, London J, Pring M, Ramsey TA et al. Erythrocyte concentrations of the lithium ion: Clinical correlates and mechanisms of action. American Journal of Psychiatry. 1978;135(9):1065-1069.
Frazer, Alan ; Mendels, J. ; Brunswick, D. ; London, J. ; Pring, M. ; Ramsey, T. A. ; Rybakowski, J. / Erythrocyte concentrations of the lithium ion : Clinical correlates and mechanisms of action. In: American Journal of Psychiatry. 1978 ; Vol. 135, No. 9. pp. 1065-1069.
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