Erectile dysfunction and subsequent cardiovascular disease

Ian M. Thompson, Catherine M. Tangen, Phyllis J. Goodman, Jeffrey L. Probstfield, Carol M. Moinpour, Charles A. Coltman

Research output: Contribution to journalArticle

610 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)2996-3002
Number of pages7
JournalJournal of the American Medical Association
Volume294
Issue number23
DOIs
StatePublished - Dec 21 2005

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Erectile Dysfunction
Cardiovascular Diseases
Smoking
Myocardial Infarction
Placebos
Confidence Intervals
Social Adjustment
Proportional Hazards Models
Prostatic Neoplasms
Body Mass Index
History

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thompson, I. M., Tangen, C. M., Goodman, P. J., Probstfield, J. L., Moinpour, C. M., & Coltman, C. A. (2005). Erectile dysfunction and subsequent cardiovascular disease. Journal of the American Medical Association, 294(23), 2996-3002. https://doi.org/10.1001/jama.294.23.2996

Erectile dysfunction and subsequent cardiovascular disease. / Thompson, Ian M.; Tangen, Catherine M.; Goodman, Phyllis J.; Probstfield, Jeffrey L.; Moinpour, Carol M.; Coltman, Charles A.

In: Journal of the American Medical Association, Vol. 294, No. 23, 21.12.2005, p. 2996-3002.

Research output: Contribution to journalArticle

Thompson, IM, Tangen, CM, Goodman, PJ, Probstfield, JL, Moinpour, CM & Coltman, CA 2005, 'Erectile dysfunction and subsequent cardiovascular disease', Journal of the American Medical Association, vol. 294, no. 23, pp. 2996-3002. https://doi.org/10.1001/jama.294.23.2996
Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA. Erectile dysfunction and subsequent cardiovascular disease. Journal of the American Medical Association. 2005 Dec 21;294(23):2996-3002. https://doi.org/10.1001/jama.294.23.2996
Thompson, Ian M. ; Tangen, Catherine M. ; Goodman, Phyllis J. ; Probstfield, Jeffrey L. ; Moinpour, Carol M. ; Coltman, Charles A. / Erectile dysfunction and subsequent cardiovascular disease. In: Journal of the American Medical Association. 2005 ; Vol. 294, No. 23. pp. 2996-3002.
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title = "Erectile dysfunction and subsequent cardiovascular disease",
abstract = "Context: The risk factors for cardiovascular disease and erectile dysfunction are similar. Objective: To examine the association of erectile dysfunction and subsequent cardiovascular disease. Design, Setting, and Participants: Men aged 55 years or older who were randomized to the placebo group (n=9457) in the Prostate Cancer Prevention Trial at 221 US centers were evaluated every 3 months for cardiovascular disease and erectile dysfunction between 1994 and 2003. Proportional hazards regression models were used to evaluate the association of erectile dysfunction and cardiovascular disease. In an adjusted model, covariates included age, body mass index, blood pressure, serum lipids, diabetes, family history of myocardial infarction, race, smoking history, physical activity, and quality of life. Main Outcome Measures: Erectile dysfunction and cardiovascular disease. Results: Of the 9457 men randomized to placebo, 8063 (85{\%}) had no cardiovascular disease at study entry; of these men, 3816 (47{\%}) had erectile dysfunction at study entry. Among the 4247 men without erectile dysfunction at study entry, 2420 men (57{\%}) reported incident erectile dysfunction after 5 years. After adjustment, incident erectile dysfunction was associated with a hazard ratio of 1.25 (95{\%} confidence interval [CI], 1.02-1.53; P=.04) for subsequent cardiovascular events during study follow-up. For men with either incident or prevalent erectile dysfunction, the hazard ratio was 1.45 (95{\%} CI, 1.25-1.69; P<.001). For subsequent cardiovascular events, the unadjusted risk of an incident cardiovascular event was 0.015 per person-year among men without erectile dysfunction at study entry and was 0.024 per person-year for men with erectile dysfunction at study entry. This association was in the range of risk associated with current smoking or a family history of myocardial infarction. Conclusions: Erectile dysfunction is a harbinger of cardiovascular clinical events in some men. Erectile dysfunction should prompt investigation and intervention for cardiovascular risk factors.",
author = "Thompson, {Ian M.} and Tangen, {Catherine M.} and Goodman, {Phyllis J.} and Probstfield, {Jeffrey L.} and Moinpour, {Carol M.} and Coltman, {Charles A.}",
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T1 - Erectile dysfunction and subsequent cardiovascular disease

AU - Thompson, Ian M.

AU - Tangen, Catherine M.

AU - Goodman, Phyllis J.

AU - Probstfield, Jeffrey L.

AU - Moinpour, Carol M.

AU - Coltman, Charles A.

PY - 2005/12/21

Y1 - 2005/12/21

N2 - Context: The risk factors for cardiovascular disease and erectile dysfunction are similar. Objective: To examine the association of erectile dysfunction and subsequent cardiovascular disease. Design, Setting, and Participants: Men aged 55 years or older who were randomized to the placebo group (n=9457) in the Prostate Cancer Prevention Trial at 221 US centers were evaluated every 3 months for cardiovascular disease and erectile dysfunction between 1994 and 2003. Proportional hazards regression models were used to evaluate the association of erectile dysfunction and cardiovascular disease. In an adjusted model, covariates included age, body mass index, blood pressure, serum lipids, diabetes, family history of myocardial infarction, race, smoking history, physical activity, and quality of life. Main Outcome Measures: Erectile dysfunction and cardiovascular disease. Results: Of the 9457 men randomized to placebo, 8063 (85%) had no cardiovascular disease at study entry; of these men, 3816 (47%) had erectile dysfunction at study entry. Among the 4247 men without erectile dysfunction at study entry, 2420 men (57%) reported incident erectile dysfunction after 5 years. After adjustment, incident erectile dysfunction was associated with a hazard ratio of 1.25 (95% confidence interval [CI], 1.02-1.53; P=.04) for subsequent cardiovascular events during study follow-up. For men with either incident or prevalent erectile dysfunction, the hazard ratio was 1.45 (95% CI, 1.25-1.69; P<.001). For subsequent cardiovascular events, the unadjusted risk of an incident cardiovascular event was 0.015 per person-year among men without erectile dysfunction at study entry and was 0.024 per person-year for men with erectile dysfunction at study entry. This association was in the range of risk associated with current smoking or a family history of myocardial infarction. Conclusions: Erectile dysfunction is a harbinger of cardiovascular clinical events in some men. Erectile dysfunction should prompt investigation and intervention for cardiovascular risk factors.

AB - Context: The risk factors for cardiovascular disease and erectile dysfunction are similar. Objective: To examine the association of erectile dysfunction and subsequent cardiovascular disease. Design, Setting, and Participants: Men aged 55 years or older who were randomized to the placebo group (n=9457) in the Prostate Cancer Prevention Trial at 221 US centers were evaluated every 3 months for cardiovascular disease and erectile dysfunction between 1994 and 2003. Proportional hazards regression models were used to evaluate the association of erectile dysfunction and cardiovascular disease. In an adjusted model, covariates included age, body mass index, blood pressure, serum lipids, diabetes, family history of myocardial infarction, race, smoking history, physical activity, and quality of life. Main Outcome Measures: Erectile dysfunction and cardiovascular disease. Results: Of the 9457 men randomized to placebo, 8063 (85%) had no cardiovascular disease at study entry; of these men, 3816 (47%) had erectile dysfunction at study entry. Among the 4247 men without erectile dysfunction at study entry, 2420 men (57%) reported incident erectile dysfunction after 5 years. After adjustment, incident erectile dysfunction was associated with a hazard ratio of 1.25 (95% confidence interval [CI], 1.02-1.53; P=.04) for subsequent cardiovascular events during study follow-up. For men with either incident or prevalent erectile dysfunction, the hazard ratio was 1.45 (95% CI, 1.25-1.69; P<.001). For subsequent cardiovascular events, the unadjusted risk of an incident cardiovascular event was 0.015 per person-year among men without erectile dysfunction at study entry and was 0.024 per person-year for men with erectile dysfunction at study entry. This association was in the range of risk associated with current smoking or a family history of myocardial infarction. Conclusions: Erectile dysfunction is a harbinger of cardiovascular clinical events in some men. Erectile dysfunction should prompt investigation and intervention for cardiovascular risk factors.

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