Epstein virus Barr-positive diffuse large B-Cell lymphoma associated with hemophagocytic lymphohistiocytosis

Jocelyn A. Ricard, River Charles, Carolina Gil Tommee, Sophia Yohe, W. Robert Bell, Margaret E. Flanagan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH.

Original languageEnglish (US)
Pages (from-to)915-920
Number of pages6
JournalJournal of Neuropathology and Experimental Neurology
Issue number8
StatePublished - Aug 1 2020
Externally publishedYes


  • Epstein Barr virus (EBV)
  • Hemophagocytic lymphohistiocytosis (HLH)

ASJC Scopus subject areas

  • General Medicine


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