Epstein-Barr viral load measurement as a marker of EBV-related disease

Hongxin Fan; Margaret L. Gulley

doi:10.1054/modi.2001.29161

Epstein-Barr viral load measurement as a marker of EBV-related disease

Hongxin Fan, Margaret L. Gulley

Pathology

Research output: Contribution to journal › Article

44 Scopus citations

Abstract

Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.

Original language	English (US)
Pages (from-to)	279-289
Number of pages	11
Journal	Molecular Diagnosis
Volume	6
Issue number	4
DOIs	https://doi.org/10.1054/modi.2001.29161
State	Published - Jan 1 2001

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Keywords

Infectious mononucleosis
Nasopharyngeal carcinoma
Post-transplant lymphoproliferation
Quantitative PCR

ASJC Scopus subject areas

Medicine(all)

Cite this

Fan, H., & Gulley, M. L. (2001). Epstein-Barr viral load measurement as a marker of EBV-related disease. Molecular Diagnosis, 6(4), 279-289. https://doi.org/10.1054/modi.2001.29161

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10.1054/modi.2001.29161