Abstract
Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-289 |
| Number of pages | 11 |
| Journal | Molecular Diagnosis |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Infectious mononucleosis
- Nasopharyngeal carcinoma
- Post-transplant lymphoproliferation
- Quantitative PCR
ASJC Scopus subject areas
- Medicine(all)
Cite this
Epstein-Barr viral load measurement as a marker of EBV-related disease. / Fan, Hongxin; Gulley, Margaret L.
In: Molecular Diagnosis, Vol. 6, No. 4, 2001, p. 279-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epstein-Barr viral load measurement as a marker of EBV-related disease
AU - Fan, Hongxin
AU - Gulley, Margaret L.
PY - 2001
Y1 - 2001
N2 - Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.
AB - Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.
KW - Infectious mononucleosis
KW - Nasopharyngeal carcinoma
KW - Post-transplant lymphoproliferation
KW - Quantitative PCR
UR - http://www.scopus.com/inward/record.url?scp=0035671576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035671576&partnerID=8YFLogxK
U2 - 10.1054/modi.2001.29161
DO - 10.1054/modi.2001.29161
M3 - Article
C2 - 11774193
AN - SCOPUS:0035671576
VL - 6
SP - 279
EP - 289
JO - Molecular Diagnosis and Therapy
JF - Molecular Diagnosis and Therapy
SN - 1177-1062
IS - 4
ER -