Epstein-Barr viral load measurement as a marker of EBV-related disease

Hongxin Fan; Margaret L. Gulley

doi:10.1054/modi.2001.29161

Epstein-Barr viral load measurement as a marker of EBV-related disease

Hongxin Fan, Margaret L. Gulley

Department of Pathology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.

Original language	English (US)
Pages (from-to)	279-289
Number of pages	11
Journal	Molecular Diagnosis
Volume	6
Issue number	4
DOIs	https://doi.org/10.1054/modi.2001.29161
State	Published - 2001

Keywords

Infectious mononucleosis
Nasopharyngeal carcinoma
Post-transplant lymphoproliferation
Quantitative PCR

ASJC Scopus subject areas

General Medicine

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10.1054/modi.2001.29161

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abstract = "Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.",

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AB - Epstein-Barr virus (EBV) is associated with a wide variety of benign and neoplastic diseases. EBV viral load assays that may prove useful in rapid assessment of disease status are now available. The two most common approaches to viral load measurement are quantitative, competitive PCR, and real-time PCR. Laboratory studies have shown that these assays are sensitive and specific for measuring EBV DNA in blood samples. Clinical investigations suggest a role for viral load measurement in predicting and monitoring EBV-associated tumors, including nasopharyngeal carcinoma, post-transplant lymphoproliferative disorder, Hodgkin's disease, and AIDS-related lymphoma. These new laboratory tools show promise in improving clinical management of affected patients.

KW - Infectious mononucleosis

KW - Nasopharyngeal carcinoma

KW - Post-transplant lymphoproliferation

KW - Quantitative PCR

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Epstein-Barr viral load measurement as a marker of EBV-related disease

Abstract

Keywords

ASJC Scopus subject areas

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