TY - JOUR
T1 - Episodic memory in progressive supranuclear palsy
T2 - a neuropsychological and neuroimaging study
AU - Macedo, Arthur Cassa
AU - Caramelli, Paulo
AU - de Paula França Resende, Elisa
AU - Mariano, Luciano Inácio
AU - Tumas, Vítor
AU - Teixeira, Antônio Lúcio
AU - Camargos, Sarah Teixeira
AU - Cardoso, Francisco Eduardo Costa
AU - de Souza, Leonardo Cruz
N1 - Publisher Copyright:
© 2022, Fondazione Società Italiana di Neurologia.
PY - 2022/9
Y1 - 2022/9
N2 - Background: Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory. Objectives: To investigate the specific brain regions underlying episodic memory impairment in PSP. Methods: Twenty-one patients with PSP and 20 healthy controls underwent the Figure Memory Test (FMT) from the Brief Cognitive Screening Battery and brain MRI. We explored correlations between gray matter volumes and memory scores in PSP patients, adjusting for age and performance on the Frontal Assessment Battery. Results: PSP patients performed worse than controls (p < 0.001) on delayed recall in the FMT. Delayed recall scores correlated to bilateral hippocampal and parahippocampal volumes in PSP patients. Conclusions: Medial temporal structures may play a role in episodic memory impairment in PSP, suggesting that amnesia in PSP is not solely due to executive dysfunction.
AB - Background: Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory. Objectives: To investigate the specific brain regions underlying episodic memory impairment in PSP. Methods: Twenty-one patients with PSP and 20 healthy controls underwent the Figure Memory Test (FMT) from the Brief Cognitive Screening Battery and brain MRI. We explored correlations between gray matter volumes and memory scores in PSP patients, adjusting for age and performance on the Frontal Assessment Battery. Results: PSP patients performed worse than controls (p < 0.001) on delayed recall in the FMT. Delayed recall scores correlated to bilateral hippocampal and parahippocampal volumes in PSP patients. Conclusions: Medial temporal structures may play a role in episodic memory impairment in PSP, suggesting that amnesia in PSP is not solely due to executive dysfunction.
KW - Episodic memory
KW - Parkinsonism
KW - Progressive supranuclear palsy
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U2 - 10.1007/s10072-022-06160-2
DO - 10.1007/s10072-022-06160-2
M3 - Article
C2 - 35633422
AN - SCOPUS:85131043229
SN - 1590-1874
VL - 43
SP - 5363
EP - 5368
JO - Neurological Sciences
JF - Neurological Sciences
IS - 9
ER -