Epigenetics of the antibody response

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Epigenetic marks, such as DNA methylation, histone post-translational modifications and miRNAs, are induced in B cells by the same stimuli that drive the antibody response. They play major roles in regulating somatic hypermutation (SHM), class switch DNA recombination (CSR), and differentiation to plasma cells or long-lived memory B cells. Histone modifications target the CSR and, possibly, SHM machinery to the immunoglobulin locus; they together with DNA methylation and miRNAs modulate the expression of critical elements of that machinery, such as activation-induced cytidine deaminase (AID), as well as factors central to plasma cell differentiation, such as B lymphocyte-induced maturation protein-1 (Blimp-1). These inducible B cell-intrinsic epigenetic marks instruct the maturation of antibody responses. Their dysregulation plays an important role in aberrant antibody responses to foreign antigens, such as those of microbial pathogens, and self-antigens, such as those targeted in autoimmunity, and B cell neoplasia.

Original languageEnglish (US)
Pages (from-to)460-470
Number of pages11
JournalTrends in Immunology
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Keywords

  • AID
  • Antibody
  • Autoimmunity
  • B cell
  • Blimp-1
  • CSR
  • Epigenetic
  • Immunoglobulin
  • Memory B cell
  • Neoplasia
  • Plasma cell
  • SHM

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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