Epigenetics of the antibody response

Guideng Li, Hong Zan, Zhenming Xu, Paolo Casali

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Epigenetic marks, such as DNA methylation, histone post-translational modifications and miRNAs, are induced in B cells by the same stimuli that drive the antibody response. They play major roles in regulating somatic hypermutation (SHM), class switch DNA recombination (CSR), and differentiation to plasma cells or long-lived memory B cells. Histone modifications target the CSR and, possibly, SHM machinery to the immunoglobulin locus; they together with DNA methylation and miRNAs modulate the expression of critical elements of that machinery, such as activation-induced cytidine deaminase (AID), as well as factors central to plasma cell differentiation, such as B lymphocyte-induced maturation protein-1 (Blimp-1). These inducible B cell-intrinsic epigenetic marks instruct the maturation of antibody responses. Their dysregulation plays an important role in aberrant antibody responses to foreign antigens, such as those of microbial pathogens, and self-antigens, such as those targeted in autoimmunity, and B cell neoplasia.

Original languageEnglish (US)
Pages (from-to)460-470
Number of pages11
JournalTrends in Immunology
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

Epigenomics
Antibody Formation
B-Lymphocytes
DNA Methylation
Plasma Cells
MicroRNAs
Genetic Recombination
Histone Code
DNA
Autoantigens
Post Translational Protein Processing
Autoimmunity
Histones
Immunoglobulins
Cell Differentiation
Antigens
Neoplasms
Proteins

Keywords

  • AID
  • Antibody
  • Autoimmunity
  • B cell
  • Blimp-1
  • CSR
  • Epigenetic
  • Immunoglobulin
  • Memory B cell
  • Neoplasia
  • Plasma cell
  • SHM

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Epigenetics of the antibody response. / Li, Guideng; Zan, Hong; Xu, Zhenming; Casali, Paolo.

In: Trends in Immunology, Vol. 34, No. 9, 01.09.2013, p. 460-470.

Research output: Contribution to journalReview article

Li, Guideng ; Zan, Hong ; Xu, Zhenming ; Casali, Paolo. / Epigenetics of the antibody response. In: Trends in Immunology. 2013 ; Vol. 34, No. 9. pp. 460-470.
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