Epigenetics of malaria parasites

Evelien M Bunnik, Karine G. Le Roch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Malaria parasites of the Plasmodium spp. have complex life cycles that include multiple stages in a vertebrate host and a mosquito vector, requiring strong regulation of their transcriptional programs for life cycle progression and survival. Epigenetic mechanisms controlling gene expression have been shown to be important for parasite proliferation during the intra-erythrocytic developmental cycle, and evidence is emerging for a role of such mechanisms in other life cycle stages. In particular, parasite-specific genes involved in pathogenesis, evasion of host immune responses, invasion of host cells, and life cycle progression are regulated at the epigenetic level. In this chapter, the various processes involved in the regulation of these parasite-specific genes and gene families will be discussed. In addition, the changes observed at the level of local chromatin structure and global nuclear organization will be described. Finally, the promise of epigenetic regulators as targets of novel antimalarial drugs will be addressed. Collectively, these topics provide insight into the unique biology of Plasmodium spp. and highlight the areas where additional research is necessary for an increased understanding of gene regulation in this deadly parasite.

Original languageEnglish (US)
Title of host publicationEpigenetics and Human Health
PublisherSpringer Verlag
Pages243-264
Number of pages22
Edition9783319550190
DOIs
StatePublished - Jan 1 2017

Publication series

NameEpigenetics and Human Health
Number9783319550190
ISSN (Print)2191-2262
ISSN (Electronic)2191-2270

Keywords

  • Chromatin
  • Chromosomes
  • Epigenetics
  • Gene expression regulation
  • Genome organization
  • Malaria

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Genetics

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  • Cite this

    Bunnik, E. M., & Le Roch, K. G. (2017). Epigenetics of malaria parasites. In Epigenetics and Human Health (9783319550190 ed., pp. 243-264). (Epigenetics and Human Health; No. 9783319550190). Springer Verlag. https://doi.org/10.1007/978-3-319-55021-3_11