Epigenetic targets in cancer and aging: dietary and therapeutic interventions

Sajid Khan, Samriddhi Shukla, Sonam Sinha, Syed Musthapa Meeran

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Introduction: Epigenetic regulation plays a critical role in normal growth and embryonic development by controlling the transcriptional activities of several genes. A growing number of epigenetic changes have been reported in the regulation of key genes involved in cancer and aging. Drugs with epigenetic modulatory activities, mainly histone deacetylase and DNA methyltransferase inhibitors, have received wider attention in aging and cancer research. Areas covered: In this review, we summarize the major epigenetic alterations in cancer and aging, with special emphasis on possible therapeutic targets and interventions by dietary as well as bioactive phytochemicals. Expert opinion: Some epigenetic-targeting drugs have received FDA approval and many others are undergoing different phases of clinical trials for cancer therapy. In addition to the synthetic compounds, several bioactive phytochemicals and dietary interventions, such as caloric restriction, have been shown to possess epigenetic modulatory activities in multiple cancers. These epigenetic modulators have been shown to delay aging and minimize the risk of cancer both in preclinical as well as clinical models. Therefore, knowledge of bioactive phytochemicals along with dietary interventions can be utilized for cancer prevention and therapy both alone and with existing drugs to achieve optimum efficacy.

Original languageEnglish (US)
Pages (from-to)689-703
Number of pages15
JournalExpert opinion on therapeutic targets
Issue number6
StatePublished - Jun 2 2016
Externally publishedYes


  • Aging
  • cancer
  • DNA methylation
  • epigenetics
  • histone modifications
  • miRNA
  • oncogenes
  • phytochemicals
  • tumor suppressors

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


Dive into the research topics of 'Epigenetic targets in cancer and aging: dietary and therapeutic interventions'. Together they form a unique fingerprint.

Cite this