Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Denis Feliers

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

Original languageEnglish (US)
Pages (from-to)668-670
Number of pages3
JournalKidney international
Volume88
Issue number4
DOIs
StatePublished - Oct 3 2015

ASJC Scopus subject areas

  • Nephrology

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