Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.
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