Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Denis Feliers

doi:10.1038/ki.2015.224

Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Denis Feliers

Department of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

Original language	English (US)
Pages (from-to)	668-670
Number of pages	3
Journal	Kidney international
Volume	88
Issue number	4
DOIs	https://doi.org/10.1038/ki.2015.224
State	Published - Oct 3 2015

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2015.224

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title = "Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease",

abstract = "Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.",

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AB - Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

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Epigenetic control of podocyte differentiation: A new target of the renin-angiotensin system in kidney disease

Abstract

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